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OA02.03. Nutrient biomarker patterns and rates of cognitive decline in dementia-free elders


We previously identified three distinct nutrient biomarker patterns associated with both psychometric and neuroimaging indices of brain health in a cross-sectional analysis. The objective of this study was to examine the relationship between the nutrient biomarker patterns and cognitive decline over 2 years.


Thirty biological markers of diet were assayed in plasma from 104 dementia-free elders in the Oregon Brain Aging Study. Principal component analysis constructed distinct nutrient biomarker patterns. A linear regression model was used to assess the association between NBPs and rate of change in Clinical Dementia Rating - sum of box score over two years.


Mean age was 87±10, 62% were female, and 10% were carrying the ApoEe4 allele. Two distinct nutrient biomarker patterns were associated with rates of cognitive decline: a vitamin pattern high in B, C, E and D (p=0.001) and a high trans fat pattern (p<0.001) associated with less and more decline over two years, respectively. These findings were independent of age, gender, education years, ApoEe4 carrier status and vascular risk factors.


A plasma nutrient profile high in certain vitamins and low in trans-fat may be prudent for maintaining cognitive function in older populations.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Bowman, G., Quinn, J., Kaye, J. et al. OA02.03. Nutrient biomarker patterns and rates of cognitive decline in dementia-free elders. BMC Complement Altern Med 12 (Suppl 1), O7 (2012).

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