From: Conessine as a novel inhibitor of multidrug efflux pump systems in Pseudomonas aeruginosa
Bacterial strain | Antibiotic | Antibiotic Minimum inhibitory concentration (mg/L) with | Fractional inhibitory concentration indexb | |||
---|---|---|---|---|---|---|
No EPIa | Conessine (20 mg/L) | PAβN (25 mg/L) | Conessine | PAβN | ||
K767 (PAO1) | Cefotaxime | 8 | 1 | 4 | 0.63 | 0.52 |
 | Erythromycin | 128 | 16 | 64 | 0.63 | 0.52 |
 | Levofloxacin | 0.25 | 0.03 | 0.03 | 0.63 | 0.15 |
 | Novobiocin | 1024 | 128 | 128 | 0.63 | 0.15 |
 | Rifampicin | 16 | 2 | 2 | 0.63 | 0.15 |
 | Tetracycline | 8 | 1 | 4 | 0.63 | 0.52 |
K1455 (PAO1-nalB) | Cefotaxime | 64 | 8 | 64 | 0.63 | 1.02 |
 | Erythromycin | 256 | 32 | 64 | 0.63 | 0.27 |
 | Levofloxacin | 2 | 0.25 | 0.25 | 0.63 | 0.15 |
 | Novobiocin | >2048 | 256 | 256 | 0.63 | 0.15 |
 | Rifampicin | 16 | 2 | 2 | 0.63 | 0.15 |
 | Tetracycline | 64 | 8 | 64 | 0.63 | 1.02 |
K1523 (PAO1-∆mexB) | Cefotaxime | 1 | 0.13 | 0.13 | 0.63 | 0.17 |
 | Erythromycin | 128 | 16 | 64 | 0.63 | 0.55 |
 | Levofloxacin | 0.06 | 0.01 | 0.01 | 0.63 | 0.17 |
 | Novobiocin | 64 | 64 | 64 | 1.50 | 1.05 |
 | Rifampicin | 16 | 2 | 2 | 0.63 | 0.17 |
 | Tetracycline | 8 | 1 | 2 | 0.63 | 0.30 |