The effect of a mindfulness-based stress intervention on neurobiological and symptom measures in adolescents with early life stress: a randomized feasibility study

Cohen, Zsofia P.; Cosgrove, Kelly T.; Akeman, Elisabeth; Coffey, Sara; Teague, Kent; Hays-Grudo, Jennifer; Paulus, Martin P.; Aupperle, Robin L.; Kirlic, Namik

doi:10.1186/s12906-021-03295-1

BMC Complementary Medicine and Therapies

Table 2 Unadjusted means, standard deviations, effect sizes, and main analyses of change from baseline to follow-up in mindfulness-based stress reduction for teens and control groups

From: The effect of a mindfulness-based stress intervention on neurobiological and symptom measures in adolescents with early life stress: a randomized feasibility study

Primary Outcomes	Mean and Standard Deviation				Statistic
Primary Outcomes	MBSR-T (n = 21)		CTRL (n = 17)		Effect	Cohen’s d	Estimate	SE	t	p
CRP					Interaction	−0.34	−0.35	0.4	− 0.88	.39
Baseline	1.16	3.82	2.39	5.75
Follow-up	0.83	1.45	0.99	1.32
IL-6					Interaction	−0.03	−0.02	0.38	−0.07	.95
Baseline	0.47	0.48	0.83	1.19
Follow-up	0.46	0.32	0.66	0.65
Cortisol
Baseline, Pre	0.12	0.89	−0.16	1.15
Baseline, Post	−0.22	0.88	0.27	1.10	Interaction	0.45	0.77	0.38	2.02	<.05
Follow-up, Pre	−0.21	1.054	0.34	0.85	Interaction	0.50	1.04	0.44	2.37	<.05
Follow-up, Post	0.05	1.16	−0.08	0.76	Interaction	0.18	0.38	0.44	0.86	.40
Stress
Baseline, Pre	2.80	1.11	2.29	0.69
Baseline, Post	3.65	0.99	3.35	0.70	Interaction	0.13	0.21	0.36	0.58	.56
Follow-up, Pre	2.13	1.19	2.55	0.82	Interaction	0.52	0.99	0.41	2.42	<.05
Follow-up, Post	3.13	1.13	3.90	0.88	Interaction	0.68	1.34	0.42	3.22	<.01
Secondary Outcomes	Mean and Standard Deviation				Statistic
Secondary Outcomes	MBSR-T (n = 21)		CTRL (n = 17)		Effect	Cohen’s d	Estimate	SE	t	p
Depression					Interaction	0.69	2.71	1.49	1.82	.08
Baseline	6.81	4.53	9.39	6.54
Follow-up	3.82	4.61	8.17	8.07
Exploratory Outcomes	Mean and Standard Deviation				Statistic
Exploratory Outcomes	MBSR-T (n = 21)		CTRL (n = 17)		Effect	Cohen’s d	Estimate	SE	t	p
Substance Use
All					Interaction	0.17	0.13	0.25	0.51	.61
Baseline	1.48	1.91	3.12	5.17
Follow-up	1.52	2.69	3.59	7.62
Alcohol					Interaction	0.51	0.4	0.28	1.41	.17
Baseline	0.71	0.85	0.59	1.06
Follow-up	0.78	1.00	1.00	1.28
Marijuana					Interaction	0.86	0.53	0.23	2.34	<.05
Baseline	0.57	1.29	0.59	1.06
Follow-up	0.50	1.34	1.08	1.68
Mindfulness					Interaction	0.21	2.41	3.95	0.61	.55
Baseline	53.83	9.92	49.47	7.25
Follow-up	58.12	12.39	55.75	15.73
Resilience					Interaction	0.04	0.19	1.94	0.1	.92
Baseline	25.1	6.67	25.18	6.87
Follow-up	25.82	7.58	27.75	8.30
FKBP5					Interaction	0.26	0.29	0.44	0.65	.52
Baseline	5.26	0.85	5.35	0.78
Follow-up	5.25	1.22	5.58	0.52

Note. Stress is the self-reported anxious arousal prior to and after the stress induction task. Cortisol is measured in μg/dL. IL-6 is measured in pg/mL. CRP is measured in mg/L.
Abbreviations: CRP C-reactive protein, CTRL Control, IL-6 interleukin-6, MBSR-T Mindfulness Based-Stress Reduction for Teens

Back to article page

ISSN: 2662-7671

Contact us

Submission enquiries: bmccomplementarymedicineandtherapies@biomedcentral.com
General enquiries: ORSupport@springernature.com