Fig. 4

Effects of La³⁺ on Rg-1–induced increases in SOCE in EA and MOVAS cells exposed to high glucose. A & B Representative traces showing the effects of high glucose, high glucose plus 125 μM La³⁺, high glucose plus 10 μM Rg-1, and high glucose plus 10 μM Rg-1 and 125 μM La³⁺ on SOCE in (A) EA and (B) MOVAS cells. C Summary data showing area under the curve (AUC) values for 500 seconds for EA and MOVAS cells. The symbol (▼) indicates the time point at which 30 μM BHQ was applied. Data are means ± SEM (n = 7–11; ^#p < 0.05, ^##p < 0.01 compared with high glucose; ^**p < 0.01 compared with high glucose plus Rg-1)