Parameter | Unit | AST | CH | FE | PE | PRO | SAB |
---|---|---|---|---|---|---|---|
AUC(0-t) | mg/L*h | 2.08 ± 0.20 | 0.92 ± 0.06 | 1.43 ± 0.23 | 2.21 ± 0.31 | 1.05 ± 0.06 | 3.40 ± 0.45 |
AUC(0-∞) | mg/L*h | 2.09 ± 0.20 | 0.94 ± 0.09 | 1.48 ± 0.24 | 2.22 ± 0.31 | 1.08 ± 0.07 | 3.70 ± 0.46 |
t1/2 | h | 3.42 ± 0.34 | 1.86 ± 0.21 | 0.90 ± 0.02 | 2.37 ± 0.20 | 0.93 ± 0.06 | 7.60 ± 3.34 |
tmax | h | 0.25 ± 0 | 0.25 ± 0 | 0.25 ± 0 | 0.25 ± 0 | 0.25 ± 0 | 0.29 ± 0.10 |
CLz/F | L/h/kg | 9.55 ± 0.81 | 21.33 ± 1.29 | 13.80 ± 2.37 | 9.15 ± 1.27 | 18.57 ± 1.07 | 5.48 ± 0.68 |
Vz/F | L/kg | 45.37 ± 6.31 | 57.19 ± 7.48 | 17.85 ± 3.28 | 31.26 ± 4.08 | 24.94 ± 1.96 | 59.83 ± 25.48 |
Cmax | mg/L | 2.27 ± 0.35 | 1.37 ± 0.06 | 1.20 ± 0.15 | 2.04 ± 0.59 | 1.43 ± 0.22 | 1.59 ± 0.33 |