Mitigative effect of caffeine against diclofenac-induced hepato-renal damage and chromosomal aberrations in male albino rats

Table 3 Mitigation effect of caffeine against diclofenac-induced bone marrow chromosomal aberrations in male albino rats

Groups	Chromosomal aberrations						Total No of aberration	Average No of aberration
Groups	R	D.C	F	C.S	D	polyploidy	Total No of aberration	Average No of aberration
Ctrl group1	3	0	0	0	4	1	8	1.0 0.34^a
Dic exposed group2	68	16	55	52	72	25	288	47.21 ± 4.10^b
Caf exposed group3	1	0	3	0	4	2	10	1.17 ± 0.40^a
Dic + Caf exposed group4	2	3	1	7	3	5	21	5.12 ± 0.92^c

Chromosomal aberration structures represented as: Dicentric (D.C), fragment (F), centric separation (C.S), deletion (D), and polyploidy. An observed induced chromosomal aberrations was detected in Dic exposed group (group 2) when compared with groups (1,3 and 4) (p < 0.05)

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