Fig. 6

Percentage of wound contraction and digital photograph of wounds. (A) The average healing time and percentage of wound healing in each group, (B) A digital photograph of the progressive wound healing activity of excision wound model in each group, (C) Wound contraction (%) on different days. The given values are the diameter of wounds expressed as mean ± SEM (n=12). a = denote when compare to the control group, b = denote when compare to the treatment II Group, (*) indicates statistically significant difference and (†) indicates statistically no significant difference from the respective group using ANOVA, followed by Turkey multiple comparisons test (P>0.05). D and E). Histological photomicrograph of hematoxylin and eosin stained sections of wound tissues. (D). Epidermis photomicrographs of sections (H and E stain; ×40). Skin appears well-rearranged epidermis. (a) stratum corneum, (b) stratum granulosum (c) stratum spinosum, (d) stratum basale, (e) papillary layer. (E). Demonstrating granulation tissues (H and E stain; ×100). Arrows pointing the events during wound healing, s: scab, re: re-epithelialization, GT: granulation tissue, nv: neovascularization, IC: inflammatory cells, mnc: mononuclear, CF: collagen fiber, F: fibroblasts, NE: new epithelium. C (Control): received an equal amount of distilled water, orally, Treatment I (T-I): received S. ilicifolium CE (100 mg/Kg BW/day for 14 days, orally), Treatment II (T-II): received S. ilicifolium CE (100 mg/kg BW/day for 21 days, orally)