Fig. 2

Visualizing the landscape of post-OMT harm. Legend: Cumulative incidence of post-OMT AEs is plotted against the post-OMT interval day upon which the patient was assessed to determine if any undesired symptoms or AEs since the preceding OMT encounter had occurred. The post-OMT interval (x-axis, days) ranged from ≤ 1 to 9 days and represents the day of patient assessment. Cumulative incidence of post-OMT AEs (y-axis, %) represents the number of AEs preceded by an OMT encounter divided by the number of OMT encounters with post-OMT interval assessment, multiplied by 100%. A total of 13 eligible studies passed methodological review and therefore contributed data for modeling. For reference, Table 3 tabulates the number of AEs preceded by an OMT encounter per AE severity grade and the number of OMT encounters with post-OMT interval assessment per study. Study identity is indicated by the manuscript reference number on each data point. Readers are directed to each numbered reference for study-specific descriptions of the observed AEs. AE severity is indicated by data point color: blue = mild (CTCAE Grade 1), yellow = moderate (Grade 2), red = severe (Grade 3), orange = life-threatening (Grade 4), and purple = death (Grade 5). A double slash breaks the y-axis at 0% cumulative incidence (horizontal dotted line) to indicate that all points clearly below the dotted line correspond to a value of 0% cumulative incidence. AE-Adverse event; CTCAE-Common Terminology Criteria for Adverse Events; OMT-Osteopathic manipulative medicine