Fig. 4

Tan IIA inhibited cancer cell proliferation and migration via the PI3K/Akt signaling pathway. (A) The protein expression levels of PI3K, Akt and p-Akt were measured after Tan IIA treatment (0, 1, 2 and 4 µM). (B, C) The expression of PI3K/Akt-related proteins, E-cadherin and vimentin was detected in H1688 cells after exposure to Tan IIA (2 µM) or LY294002 (10 µM) for 48 h. The effect of LY294002 on cell migration (D, E, F) and viability (G) were analyzed. Compared with control (n = 3), ns > 0.05, * P < 0.05, ** P < 0.01, *** P < 0.001