Effects of Melissa officinalis (lemon balm) consumption on serum lipid profile: a meta-analysis of randomized controlled trials

Table 1 The main characteristics of the included studies

Study, Year	Study design	Follow-up	Treatment	Administered daily dose	control	Clinical outcome				Patients	No. of patients
Study, Year	Study design	Follow-up	Treatment	Administered daily dose	control	TC	TG	LDL	HDL	Patients	No. of patients
Asadi et al. (2019)	Randomized, double-blinded, placebo-controlled study	12 weeks	Hydroalcoholic extract of M. officinalis	700 mg/d- two capsules per day (350 mg)	Placebo	↓	↓*	↑	↑**	Type 2 diabetes	62
Jandaghi et al. (2016)	Randomized, double-blinded, placebo-controlled study	2 months	M. officinalis leaf powder	3000 mg/d- three capsules per day (1000 mg)	Placebo	↓	↓	↓*	↓	Borderline hyperlipidemia	58
Javid et al. (2018)	Randomized, double-blinded, placebo-controlled study	8 weeks	M. officinalis leaf powder	3 g per day (3 capsules)	Placebo	↓***	↓***	↓***	↑***	Chronic stable angina	73
Kheirkhah et al. (2021)	Randomized open-label controlled trial	12 weeks	Tea Bag of M. officinalis	2 gr twice per day (4 gr)	Placebo	↓**	↓*	↓	↑	Premature ventricular contraction	59
Kim et al. 1800 (2023)	Randomized, double-blinded, placebo-controlled study	24 weeks	M. officinalis extract	1800 mg/d ALS-L1023	Placebo	↑	↓	↓	↑	Non-Alcoholic Fatty Liver Disease	33
Kim et al. 1200 (2023)	Randomized, double-blinded, placebo-controlled study	24 weeks	M. officinalis extract	1200 mg/d ALS-L1023	Placebo	↓*	↓*	↓*	↑	Non-Alcoholic Fatty Liver Disease	32

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